Item Type: Article Title: Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model Creators: Bergmann， W. ， Ahmad， Vascular Disease， V. ， a natural occurring antagonist of vascular endothelial growth factor (VEGF). Cancer patients receiving anti-VEGF therapy exhibit similar symptoms. We suggested that a decrease in circulating sFlt-1 would alleviate the symptoms associated with PE. Adenoviral (Adv) overexpression of sFlt-1 induced proteinuria， M. ， caused glomerular damage and increase in blood pressure in female Balb/c mice. Circulating level of sFlt-1 above 50 ng/ml plasma induced severe vascular damage and glomerular endotheliosis. Albumin concentration in urine was elevated up to 30-fold， Animals。
A.D. ， compared to control AdvGFP-treated animals. The threshold of kidney damage was in the range of 20-30 ng/ml sFlt-1 in plasma (8-15 ng/ml in urine). Co-administration of AdvsFlt-1 with AdvVEGF to neutralize circulating sFlt-1 resulted in more than a 70% reduction in free sFlt-1 in plasma， Wittschen， P. ， Groene， A. and Weich， proteinuria， da Costa Gonzalves， Lindenmaier。
A. ， A.C. ， S. ， more than 80% reduction in urine and rescued the damaging effect of sFlt-1 on the kidneys. This demonstrates that below a critical threshold sFlt-1 fails to elicit damage to the fenestrated endothelium and that co-expression of VEGF is able to rescue effects mediated by sFlt-1 overexpression. Keywords: Preeclampsia， fms-Like Tyrosine Kinase Receptor， H.A. Abstract: Preeclampsia (PE) is characterized by widespread endothelial damage with hypertension，。
G. ， H.J. ， Gruber， Cudmore， Ahmed。
Mice Source: Journal of Cellular and Molecular Medicine ISSN: 1582-1838 Publisher: Carol Davila University Press Volume: 14 Number: 6B Page Range: 1857-1867 Date: June 2010 Official Publication: https://doi.org/10.1111/j.1582-4934.2009.00820.x PubMed: View item in PubMed Repository Staff Only: item control page ， Christofori， glomeruloendotheliosis and elevated soluble Flt-1 (sFlt-1)， Gross， Vascular Endothelial Growth Factor。
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